MUSIQ Innovation Newsletter n. 3 | October 2021

The new MUSIQ Innovation newsletter on RAMAN SPECTROSCOPY: From applications to laser sources and detectors is available online and as a PDF . Each newsletter is written by three of MUSIQ’s Early Stage Researchers (ESRs) who choose their topics themselves to develop into an interesting read for our stakeholders. Our Innovation Newsletter n. 3 was written collaboratively by Jan Majer (ESR13), Dominykas Gudavičius (ESR15) and Ediz Herkert (ESR8).

Section n. 1
Prospects of stimulated Raman scattering in pharma research

Before a novel medicine can be introduced on the market, it needs to undergo a drug development process which today on average consists of six stages. The drug development process from target discovery to the launch can  take up to 15 years. Read more

Section n. 2
Light sources for CARS microscopy

In coherent anti-Stokes Raman scattering (CARS) microscopy two laser beams are used to produce radiation at a third wavelength when energy difference between pulses matches vibrational energy of a sample. For this vibrationally specific microscopy method it is critical to have a reliable wavelength-tunable light source to address different Raman bands. Optical parametric amplifiers (OPAs) and oscillators (OPOs) are well suited for this task. Read more

Section n. 3
EMCCD and sCMOS cameras for scientific imaging
A comparison of the key figures of current camera models

The emergence of faster and more sensitive scientific cameras allows to acquire images with unprecedented sensitivity and speed. This is particularly important for applications in life sciences where techniques like Raman imaging require low-noise detectors while other techniques like fluorescent correlation spectroscopy rely on frame rates in the upper kilohertz range. To obtain meaningful data it is therefore essential to choose the scientific camera according to the experimental conditions.  Read more

Thomas Deckert (ESR11) presents at the CLEO/Europe 2021

From 21 – 25 June 2021 the bi annual Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) took place online at the World of Photonics Congress 2021 The CLEO/Europe-EQEC brings together universities, industry scientists and researchers to discuss basic research in laser physics, nonlinear optics and quantum optics. Thomas Deckert, our MUSIQ ESR11, represented the project by presenting his results on Ultrafast Coherent Spectroscopy with Field Resolution at Mid-Infrared and THz Frequencies.

MUSIQ Innovation Newsletter n. 2 | March 2021

Our second MUSIQ Innovation Newsletter on ULTRAFAST SPECTROSCOPY: RECENT PROGRESS AND CHALLENGES is available online as a PDF . We would like to thank Vasilis Petropoulos (ESR5), Vikramdeep Singh (ESR2) and Frank Quintela (ESR12) who delivered us this exciting read.

Section n. 1
Broadband laser sources for ultrafast spectroscopy

The continuous progress in laser technology along with technical advances and conceptual breakthroughs, expand the application potential of Ultrafast Spectroscopy. Read more

Section n. 2
Pulse shaping techniques for ultrafast spectroscopy

This section focuses on programmable femtosecond pulse-shaping techniques for multidimensional ultrafast spectroscopy. Read more

Section n. 3
Resources for improving data acquisit/newsletter/ion and coherence characterization in ultrafast spectroscopy

This section focuses on: 1. eliminating heat-induced signals by controlling pulse spectra through pulse shaping, 2. compressive sensing to shorten the data acquisition time, and 3. simultaneous frequency and time resolution using time-frequency transforms.  Read more

COVID can’t stop the MUSIQ – MUSIQ virtual conference

From the 13th to the 15th of January the ESRs and the MUSIQ partners came together once again to discuss their progress on the development of next-generation optical microscopy.

The conference was hosted virtually from GSK in Stevenage – hence we dubbed it COVID can’t stop the MUSIQ – and brought together scientists from 9 countries spanning across 9 time zones. All ESRs had a chance to share and discuss their science with some of the greatest scientific minds in non-linear optics, plasmonics, spectroscopy or mass spectrometry from the safety of their homes.

The main focus of this conference were the ESRs and their talks on their scientific progress they achieved prior to this meeting, covering the fields of ultrafast spectroscopy and optical microscopy exploiting quantum coherent nonlinear phenomena. The management and organisation of the event was in the hands of Jan Majer and Nicole Slesiona, puppeteered by Steve Hood (GSK) and Paola Borri (Cardiff University). ESRs were responsible for the chairing and the management of the individual sessions to prepare each and every one for their future in the scientific community.

Apart from peer-to-peer scientific discussions among the students and discussions with the PIs, professors Ian Gilmore, Michel Orrit, Enrico Gratton and Christoph Lienau, members of our advisory board, accepted the invitation to deliver talks as Keynote speakers. They shared their expertise and their innovative approaches to further everyone’s insights into the possibilities that lay in front to bring the scientific community closer to broaden everyone’s knowledge about ultrafast quantum processes:

  • Metabolic imaging with subcellular resolution using mass spectrometry, held by Prof. Ian Gilmore
  • Optical Microspectroscopy of Single Molecules and Nanoparticles, held by Prof. Michel Orrit
  • Single cell physiological characterization in living tissue, held by Prof. Enrico Gratton
  • Coherent ultrafast charge and energy transfer processes in nanostructures, held by Prof. Christoph Lienau

MUSIQ Innovation Newsletter n. 1 | October 2020<

We are happy to present to you our first MUSIQ Innovation Newsletter written by three of our Early Stage Researchers, Andrea Pruccoli (ESR10), Eric Michele Fantuzzi (ESR7) and Thomas Deckert (ESR11) on LASER SOURCES FOR MULTIPHOTON MICROSCOPY. The articles are also available for download as PDF.

Download as PDF

Section n. 1
Laser sources for Coherent Raman Scattering Microscopy

State of the art and new technologies – How to choose the best laser source for your SRS experiments

The laser source is arguably the core component in any CRS experiment. In this brief article we explain what the most common laser sources for CRS microscopy are and try to give guidelines for their selection. Read more

Section n. 2
Light sources for harmonic generation and multiphoton fluorescence microscopy

This section informs about the latest laser sources and their requirements for biophotonics applications. Specifically, the field of multiphoton microscopy (MPM) was subject to vast developments in recent years, pushed by the development of pulsed laser sources. This article will provide an overview of specific requirements of MPM experiments, and therein requirements for the laser sources themselves. Read more

MUSIQ E-Schools on Nano-Plasmonics and applications

The 2nd MUSIQ week was originally planned to be a face-to-face event in June 2020.  Due to the impact of the coronavirus pandemic, the school was organised online and held earlier to keep the ESRs engaged during the period where access to the various research labs was restricted. The 2nd School “Nano-Plasmonics and applications”  organised by our MUSIQ partner, ICFO, from 28th April – 7th May 2020 in six half day sessions and lecture topics related to the subject. 

  • Diffraction limited fluorescence microscopy and super-resolution approaches – Maria Garcia-Parajo (ICFO)
  • Introduction to nanoplasmonics – Niek van Hulst (ICFO)
  • Nanofabrication and integration approaches towards Neuroplasmonics – Francesco de Angelis (Istituto Italiano di Tecnologia)
  • Nanoplasmonics & single molecules using DNA origamis – Guillermo Acuña (Université de Fribourg)
  • Plasmonic based fluorescence enhancement & FRET manipulation – Jerome Wenger (Fresnel Institute)
  • Nanoplasmonics for ultra-sensitive detection & living cell applications – Maria Garcia-Parajo (ICFO)

The virtual training session was open to externals and attracted 50-60 additional participants from outside of the MUSIQ Network. We would like to thank Prof. Maria Garcia-Parajo  from ICFO for organising this event and for the active participation from everyone who joined.

MUSIQ E-Schools on Ultrafast optics and spectroscopy

The COVID-19 has restricted the movement of people which has affected many including our Early Stage Researchers who would be required to travel for their research and training, a key aspect in European Training Networks (ETNs).

To find a way for the the MUSIQ ESRs to work together in these difficult times and to manage their “mobility” The MUSIQ network is organising online e-school training modules to offer the MUSIQ Early Stage Researchers and other students from our partner organisations the opportunity to receive virtual training on ultrafast optics and spectroscopy related topics from our experts within our network.

From the 16.- 23. April 2020 ​the MUSIQ PIs set up 6 virtual training sessions on topics related to Ultrafast optics and spectroscopy​. The presenters consisted of experts in the field within and outside of the MUSIQ network. Details on the sessions can be found below:

  • 16. April – Introduction to Ultrafast Optics and Spectroscopy
    Giulio Cerullo
  • 17. April – Second- and Third-order Non-Linear Optics
    Cristian Manzoni
  • 20. April – Multi-dimensional Spectroscopy
    Margherita Maiuri
  • 21. April – Exercises of Non-linear Optics and Ultrafast Spectroscopy
    Rocio Borrego-Varillas
  • 22. April – Coherent Optical Spectroscopy of Nanostructures
    Wolfgang Langbein
  • 23. April – Ultrafast Plasmonics
    Daniele Brida

We would like to thank the MUSIQ network for their quick thinking and adaption to the current situtation and for bringing together such a interesting E-School and the ESRs for their active contributions.

MUSIQ on Instagram

The MUSIQ project has set up an Instagram account where our ESRs post regular photos and updates on themselves and their work within the project. Follow us online for an insight into the life as a MUSIQ ESR and updates on training and research.

Follow us @musiq.msca

1st MUSIQ Week, 9-14 December 2019

The 1st Week School took place in Marseille, France from 9-14 December 2019 and brought together the MUSIQ partners and the ESRs for the first time to discuss developing the next-generation optical microscopy exploiting quantum coherent nonlinear phenomena. The program consisted of different networking and training elements starting off with a two day symposium where all PIs presented their research and activities within the MUSIQ project. The ESRs also each had the opportunity to present themselves and their individual ESR projects and had organised posters related to their research which helped all participants to receive a detailed overview of how each person will be contributing to the project.

The second element of the 1st MUSIQ week was dedicated to the training of the ESRs. Over the next four days the ESRs received the first sessions of the multi-disciplinary training programme that specifically addresses the scientific, technical and career development challenges associated with MUSIQ’s vision of developing the next-generation optical microscopy exploiting quantum coherent nonlinear phenomena. These topics included the 1st School on Molecular nonlinear optics held by CNRS and two transferable skills trainings on time project management for scientists and on gender equality held by Hertz.

The full MUSIQ training programme is structured around 6 weeks of network-wide face-to-face events that will equip the ESRs with the combination of research-related and transferable competences needed to succeed in the European science, technology and innovation sector.

You can follow the MUSIQ ESRs via Instagram https://www.instagram.com/musiq.msca

Kick off Meeting MUSIQ

On the 2nd of April, the MUSIQ project officially kicked-off with the first face-to-face meeting with the whole consortium. All MUSIQ Beneficiaries had the chance to meet at the coordinating Cardiff University, School of Biosciences. The project Coordinator, Prof Paola Borri gave everyone a warm welcome and started the meeting by introducing and updating all participants on the objectives of the four year project. The meeting offered an engaging platform to discuss the research that will take place as well as the recruiting strategy for the 15 open positions.

The atmosphere was full of energy and the 11 represented partners from 8 countries are excited to dive into the project. We will look forward to the collaborations and results that are going to follow within the next 48 months.