Before a novel medicine can be introduced on the market, it needs to undergo a drug development process which today on average consists of six stages. The drug development process from target discovery to the launch can take up to 15 years. Read more
In coherent anti-Stokes Raman scattering (CARS) microscopy two laser beams are used to produce radiation at a third wavelength when energy difference between pulses matches vibrational energy of a sample. For this vibrationally specific microscopy method it is critical to have a reliable wavelength-tunable light source to address different Raman bands. Optical parametric amplifiers (OPAs) and oscillators (OPOs) are well suited for this task. Read more
The emergence of faster and more sensitive scientific cameras allows to acquire images with unprecedented sensitivity and speed. This is particularly important for applications in life sciences where techniques like Raman imaging require low-noise detectors while other techniques like fluorescent correlation spectroscopy rely on frame rates in the upper kilohertz range. To obtain meaningful data it is therefore essential to choose the scientific camera according to the experimental conditions. Read more
From 21 – 25 June 2021 the bi annual Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) took place online at the World of Photonics Congress 2021 The CLEO/Europe-EQEC brings together universities, industry scientists and researchers to discuss basic research in laser physics, nonlinear optics and quantum optics. Thomas Deckert, our MUSIQ ESR11, represented the project by presenting his results on Ultrafast Coherent Spectroscopy with Field Resolution at Mid-Infrared and THz Frequencies.
This section focuses on: 1. eliminating heat-induced signals by controlling pulse spectra through pulse shaping, 2. compressive sensing to shorten the data acquisition time, and 3. simultaneous frequency and time resolution using time-frequency transforms. Read more
The laser source is arguably the core component in any CRS experiment. In this brief article we explain what the most common laser sources for CRS microscopy are and try to give guidelines for their selection. Read more
This section informs about the latest laser sources and their requirements for biophotonics applications. Specifically, the field of multiphoton microscopy (MPM) was subject to vast developments in recent years, pushed by the development of pulsed laser sources. This article will provide an overview of specific requirements of MPM experiments, and therein requirements for the laser sources themselves. Read more
The 2nd MUSIQ week was originally planned to be a face-to-face event in June 2020. Due to the impact of the coronavirus pandemic, the school was organised online and held earlier to keep the ESRs engaged during the period where access to the various research labs was restricted. The 2nd School “Nano-Plasmonics and applications” organised by our MUSIQ partner, ICFO, from 28th April – 7th May 2020 in six half day sessions and lecture topics related to the subject.
Diffraction limited fluorescence microscopy and super-resolution approaches – Maria Garcia-Parajo (ICFO)
Introduction to nanoplasmonics – Niek van Hulst (ICFO)
Nanofabrication and integration approaches towards Neuroplasmonics – Francesco de Angelis (Istituto Italiano di Tecnologia)
Nanoplasmonics & single molecules using DNA origamis – Guillermo Acuña (Université de Fribourg)
Nanoplasmonics for ultra-sensitive detection & living cell applications – Maria Garcia-Parajo (ICFO)
The virtual training session was open to externals and attracted 50-60 additional participants from outside of the MUSIQ Network. We would like to thank Prof. Maria Garcia-Parajo from ICFO for organising this event and for the active participation from everyone who joined.
The EU funded project MUSIQ will officially start on 1st April 2019
and aims to develope with the help of 15 early stage researchers (ESRs)
the next generation optical microscopy exploitin quantum coherent
It trains the ESRs on a unique mixture of experimental and
computational skills at the physics/chemistry/life science interface. By
bringing together a unique team of 6 world-leading academic groups, at
the forefront of nonlinear optical microscopy and ultrafast coherent
light-matter interaction phenomena, and 6 high tech companies, to
translate the results into biomedical/pharmaceutical real-world
The project will run for 48 months under the coordination of Prof Paola Borri from the Cardiff University.